Status:
COMPLETED
Epigenetics in the Aging Process
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Aging
Eligibility:
All Genders
14-90 years
Brief Summary
This study will examine the role of epigenetics (heritable changes in gene function that occur without a change in DNA sequence) in the aging process. DNA is the primary genetic material, responsible ...
Detailed Description
Normal human lifespan is marked by a complex series of developmental events, relative stability during adulthood, and ultimately a gradual decline in viability. Biological clocks presumably underlie t...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age 21-30 or 65-90, female or male
- Normal liver function, renal function adjusted for age
- Written informed consent
- EXCLUSION CRITERIA:
- Down's or other premature aging syndromes
- Mastectomies: skin involvement in the malignant process or damage due to prior radiation therapy
- Active skin infection
- Skin damage due to photoaging will be noted but will not be a basis for exclusion
Exclusion
Key Trial Info
Start Date :
September 23 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 5 2021
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00242255
Start Date
September 23 2008
End Date
February 5 2021
Last Update
February 9 2021
Active Locations (4)
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1
GW University Medical Center
Washington D.C., District of Columbia, United States, 20037
2
Suburban Hospital
Bethesda, Maryland, United States, 20814
3
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
4
Virginia Commonwealth University
Richmond, Virginia, United States, 23284