Status:
COMPLETED
The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane
Lead Sponsor:
University Health Network, Toronto
Conditions:
Anesthesia
Eligibility:
FEMALE
18-80 years
Phase:
PHASE3
Brief Summary
The twilight phase between being asleep and awake during recovery from anesthesia is a precarious time fraught with risks to the post-operative patient. Hyperventilation accelerates the elimination of...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Elective gynecological procedure
- ASA I-III
- Age 18-80 years
- Signed informed consent
- Exclusion criteria:
- ASA IV
- Patients with contra-indications to Sevoflurane anesthesia or other anesthetics included in the protocol
- Active smoking, asthma or other history of hyper-reactive airway disease
- History of chronic obstructive lung disease limiting exercise
- History of angina, previous myocardial infarction, valvular heart disease, or heart surgery
- Presence of heart murmurs or neck bruits
- ECT abnormalities including atrial fibrillation, prolonged P-R interval, prolonged Q-T interval, presence of Q waves in inferior, anterior or lateral leads, criteria for left ventricular hypertrophy, T-wave abnormalities,
- History of difficult airway access
- Pulmonary hypertension and/or right ventricle dysfunction
- History of bulous emphysema, and/or spontaneous pneumothorax
- History of alcohol or drugs abuse
- Known history of psychiatric illness and/or medications
- Patients that required postoperative mechanical ventilation for any reason
Exclusion
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
End Date :
December 1 2008
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00242671
Start Date
October 1 2005
End Date
December 1 2008
Last Update
August 5 2010
Active Locations (1)
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1
Toronto General Hospital, University Health Network
Toronto, Ontario, Canada, M5G 2C4