Status:
RECRUITING
Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Malignant Pleural Mesotheliomas NOS
Esophageal Cancers NOS
Eligibility:
All Genders
2+ years
Brief Summary
Background: * Chromatin is is the structural building block of a chromosome. It is found inside the nucleus of the cell and consists of a complex of DNA and protein. * Cancers of the lung, pleura (lu...
Detailed Description
Background: * Lung and esophageal cancers as well as malignant pleural mesotheliomas exhibit epigenetic perturbations that may impact the clinical course of these neoplasms. * To date, epigenetic alt...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients with potentially malignant or suspicious lesions, or with biopsy proven lung cancers or esophageal cancers, malignant pleural mesotheliomas, mediastinal or chest wall neoplasms, thymoma/thymic carcinomas, or thoracic metastases from cancers of non-thoracic origin.
- Patients must have an ECOG performance score of 0-2.
- Patients must be 2 years of age or older. Note: Patients \>= 2 and \< 18 years of age may participate in research sample collection if the tissue acquisition is performed during a clinically indicated surgical procedure, and the sampling of tissue, blood and urine does not add risk to the clinically indicated procedures.
- Patients must be aware of the nature of his/her illness. The patient must be willing to undergo standard intervention that may include endoscopic biopsies of tumor and adjacent normal tissues, and to provide blood and urine samples to support ongoing laboratory research endeavors pertaining to the epigenetics of thoracic malignancies.
- Ability of subject, their parents/guardians or legally authorized representative (LAR) to understand and the willingness to sign a written informed consent document.
- EXCLUSION CRITERIA:
- None
Exclusion
Key Trial Info
Start Date :
November 9 2005
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
1310 Patients enrolled
Trial Details
Trial ID
NCT00242723
Start Date
November 9 2005
Last Update
October 7 2025
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892