Status:
COMPLETED
Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Aneurysms
Arteriovenous Malformations
Eligibility:
All Genders
13-80 years
Phase:
PHASE1
Brief Summary
The purpose of this pilot study is to investigate the use of minocycline and doxycycline as medical therapy for inoperable or partially treated arteriovenous malformations (AVMs) and giant aneurysms.
Detailed Description
Arteriovenous malformations (AVMs) are a treatable cause of stroke in young adults. The processes by which AVMs and giant aneurysms grow in size and spontaneously bleed are unknown. The primary reason...
Eligibility Criteria
Inclusion
- Giant aneurysms or brain arteriovenous malformations (BAVM)
- Female patients of child bearing age using effective birth control, males
- Creatinine no greater than 2.0 mg/dl
- ALT no greater than 2 times upper limit of control
Exclusion
- Unstable medical illness
- Contraindications to Tetracycline
- History of vestibular disease, (except benign positional vertigo)
- Prior tetracycline use within 2 mos of baseline visit.
- History of noncompliance with treatment or other protocols
- History of systemic lupus
- Patients not eligible for MRI
Key Trial Info
Start Date :
July 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2008
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT00243893
Start Date
July 1 2004
End Date
October 1 2008
Last Update
October 9 2013
Active Locations (1)
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1
University of California
San Francisco, California, United States, 94143