Status:
COMPLETED
Ultrasound and Chemotherapy of Breast Cancer: Relationship Between Early Vascular Changes of the Tumor and Late Tumoral Response
Lead Sponsor:
University Hospital, Tours
Conditions:
Breast Cancer
Eligibility:
FEMALE
18-75 years
Phase:
NA
Brief Summary
This study intends to assess the ability of contrast-enhanced ultrasound to make the efficacy of chemotherapy in breast cancer precise. This real-time noninvasive and feasible imaging technique allow...
Detailed Description
The main objective of the study is to evaluate the early vascular changes of the tumor during neoadjuvant chemotherapy compared to the clinical or MRI or histological response.
Eligibility Criteria
Inclusion
- Breast tumor (size equal to or greater than 3 cm.). Patients with diagnosis of benign breast tumor based on biopsy will be excluded from the study after the first ultrasound examination.
- Neoadjuvant chemotherapy is programmed when an epithelial carcinoma is diagnosed by histology.
- Performance status = 0, 1 or 2
- No previous surgery or local radiotherapy
Exclusion
- Psychiatric disorders
- Vital threat due to other disease
- Vital prognosis \< 3 months
- Biopsy of the lesion performed within 1 month before the ultrasonography
- Patient known to have a coronary syndrome
- Unstable angina and myocardial infarction
- Acute cardiac failure, Class III/IV cardiac failure
- Several arrhythmias
- Acute endocarditis
- Prosthetic valves
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
End Date :
February 1 2007
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00245869
Start Date
March 1 2004
End Date
February 1 2007
Last Update
February 21 2007
Active Locations (1)
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1
University Hospital of Tours
Tours, France, 37044