Status:
COMPLETED
Circadian Rhythms and Sleep in Familial DSPS and ASPS
Lead Sponsor:
Northwestern University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Circadian Rhythm Sleep Disorder
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to determine the properties of circadian rhythms and sleep propensity in familial advanced and delayed sleep phase syndrome (DSPS).
Detailed Description
BACKGROUND: Tremendous progress in the past few years has led to the identification of several circadian clock genes. This now makes it possible to determine how alterations of human circadian clock ...
Eligibility Criteria
Inclusion
- Inclusion Criteria for ASPS Participants:
- Morning type score on the Horne-Ostberg questionnaire
- Advanced melatonin onset
- Inclusion Criteria for DSPS Participants:
- Evening type score on the Horne-Ostberg questionnaire
- Delayed melatonin onset
- Inclusion Criteria for Controls:
- A stable sleep/wake pattern with a normal phase relationship to the environment and no history of sleep disorders
- Exclusion Criteria for all subjects:
- Sleep disorder, other than DSPS or ASPS, as assessed by the Pittsburgh Sleep Quality Index and/or by polysomnogram
- History of cognitive or other neurological disorders
- History of Diagnostic and Statistical Manual-IV criteria for any major psychiatric disorder, alcohol or substance abuse
- Abnormal mood as assessed by the Hamilton Depression Scale
- History of, or concurrent, unstable or serious medical illness
- Current use of psychoactive medications, including antidepressants, anxiolytics, neuroleptics, anticonvulsants, hypnotics, and stimulant medications
- Shift work
- Having a daily caffeine intake greater than 4 cups per day
- Smoking
- Travel across more than 2 time zones within 90 days of the study
- Pregnancy or the desire to become pregnant during the study period
Exclusion
Key Trial Info
Start Date :
September 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 27 2024
Estimated Enrollment :
156 Patients enrolled
Trial Details
Trial ID
NCT00246454
Start Date
September 1 2003
End Date
March 27 2024
Last Update
March 29 2024
Active Locations (1)
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1
Northwestern University
Chicago, Illinois, United States, 60611