Status:
COMPLETED
Assessment of Insulin Production From Native Pancreas in Patients With Pancreas Transplants
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Long-Functioning Pancreas Allografts
Pancreas Transplant
Eligibility:
All Genders
18+ years
Brief Summary
This study will examine whether insulin-producing cells in the pancreas (beta cells) can recover in patients with type 1 diabetes who have had a pancreas transplant. In type 1 diabetes, the body's imm...
Detailed Description
Type 1 diabetes mellitus (T1DM) is thought to result from an autoimmune destruction of insulin producing beta-cells found within the pancreatic islets of Langerhans. In addition to the autoimmune proc...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients will be included if:
- Age greater than or equal to 18
- GFR greater than 50 ml/min/1.73 m2
- History consistent with T1DM prior to pancreas transplant
- EXCLUSION CRITERIA:
- Liver dysfunction (elevated liver enzymes, clinical evidence of portal hypertension)
- coagulopathy (elevated INR or Partial Thromboplastin Time)
- History of repeated instrumentation/cannulation in the jugular or femoral vessels
- Dye allergy
- Pregnancy
- Known vascular anomalies
- Anemia with Hgb less than 10
Exclusion
Key Trial Info
Start Date :
October 26 2005
Trial Type :
OBSERVATIONAL
End Date :
August 15 2007
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00246844
Start Date
October 26 2005
End Date
August 15 2007
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892