Status:
COMPLETED
Comparison of a "Step-Up" Versus a "Step-Down" Treatment Strategy for Patients With New Onset Dyspepsia in General Practice (The DIAMOND-Study)
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
ZonMw: The Netherlands Organisation for Health Research and Development
Conditions:
Dyspepsia
Gastrointestinal Diseases
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study was to determine which treatment strategy, the step-up or the step-down treatment strategy, is the most cost-effective treatment for patients with new onset dyspepsia in prim...
Detailed Description
Dyspepsia is very common in the population. On an annual basis, 20%-40% of the general population suffers from upper gastrointestinal symptoms. The prevalence of dyspepsia presenting in primary care i...
Eligibility Criteria
Inclusion
- Presence of a new episode of dyspepsia, defined as episodic or persistent symptoms including abdominal pain or discomfort and which are, in the opinion of the general practitioner, referable to the upper gastrointestinal tract.
- Over 18 years of age
- Informed consent (written) given.
Exclusion
- Use of prescribed acid suppressive medication during 3 months before consult
- Investigated by upper gastrointestinal endoscopy one year before inclusion
- Malignancy
- Contraindication to the study medication
- Pregnancy
- Alarming symptoms like weight loss, bleeding, and disturbed food passage
- Patients with insufficient comprehension of the Dutch language
Key Trial Info
Start Date :
October 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2007
Estimated Enrollment :
664 Patients enrolled
Trial Details
Trial ID
NCT00247715
Start Date
October 1 2003
End Date
January 1 2007
Last Update
August 29 2007
Active Locations (3)
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1
Radboud University Nijmegen Medical Center
Nijmegen, Gelderland, Netherlands, 6500 HB
2
Maastricht University
Maastricht, Limburg, Netherlands, 6200 MB
3
UMC Utrecht
Utrecht, Utrecht, Netherlands