Status:
COMPLETED
Effectiveness of Nefazodone and Bupropion in Treating Marijuana Dependent Individuals
Lead Sponsor:
National Institute on Drug Abuse (NIDA)
Conditions:
Marijuana Abuse
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
Recent research has identified the following withdrawal symptoms to be associated with abruptly stopping marijuana use: anxiety, irritability, bodily aches and pains, and difficulty sleeping. These sy...
Detailed Description
There have been few controlled studies that focus on treatments for marijuana dependence. The symptoms associated with marijuana withdrawal, including anxiety, irritability, bodily aches and pains, an...
Eligibility Criteria
Inclusion
- Meets DSM-IV criteria for current marijuana dependence
- Uses at least 5 marijuana joints per week
- Currently seeking treatment for marijuana dependence
- Used marijuana in a maladaptive pattern in the 6 months prior to study entry
Exclusion
- History of seizures or unexplained loss of consciousness
- Significant and unstable psychiatric condition (e.g., schizophrenia, bipolar disorder)
- Chronic organic mental disorder
- Dependent on any substances of abuse other than marijuana
- Currently at significant suicidal risk
- Unstable physical disorder that may represent a severe untreated condition, such as hypertension (blood pressure greater than 150/90), elevated transaminase levels, or unstable diabetes
- Current or suspected coronary vascular disease
- Has taken a monoamine oxidase inhibitor in the 2 weeks prior to study entry
- Currently taking terfenedine, cisapride, astemizole, or pimozide
- History of an allergic reaction to bupropion or nefazodone
- If female, pregnant, breastfeeding, or unwilling to use an adequate method of contraception for the duration of the study
Key Trial Info
Start Date :
September 1 2000
Trial Type :
INTERVENTIONAL
End Date :
September 1 2004
Estimated Enrollment :
132 Patients enrolled
Trial Details
Trial ID
NCT00249509
Start Date
September 1 2000
End Date
September 1 2004
Last Update
January 16 2017
Active Locations (1)
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1
New York State Psychiatric Institute
New York, New York, United States, 10032