Status:
TERMINATED
Microbiologic Effect of Selective Decontamination of the Digestive Tract With Colistin, Gentamicin and Nystatin
Lead Sponsor:
University of Pittsburgh
Conditions:
VRE Colonization
Eligibility:
All Genders
18+ years
Brief Summary
Selective decontamination of the digestive tract (SDD) is a prophylactic measure aimed at reducing Gram negative flora in the gut with an aim to reduce nosocomial infections such as ventilator-associa...
Detailed Description
Study Design We will enroll 40 consecutive patients with VRE colonization who are admitted to Transplant ICU of Montefiore Hospital. Methods: A total of 40 patients will be randomized to SDD or no S...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients in ICU who are identified as having VRE colonization by Infection Control's surveillance swabs or by the presence of VRE in clinical specimens.
- Patients must be above \>18 years of age.
- Patients in whom there is an expectation of at least 4 days of mechanical ventilation.
- Presence of a nasogastric or enteral feeding tube.
- Written informed consent from patient or a proxy.
- Exclusion criteria:
- Allergy to colistin, gentamicin or nystatin.
- Pregnancy.
- Intestinal transplant or multivisceral transplant.
Exclusion
Key Trial Info
Start Date :
Trial Type :
OBSERVATIONAL
End Date :
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00250133
Last Update
September 3 2007
Active Locations (1)
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1
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213