Status:
COMPLETED
An Eight-Week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression
Lead Sponsor:
Sanofi
Conditions:
Depressive Disorder
Eligibility:
All Genders
18-64 years
Phase:
PHASE3
Brief Summary
The purpose of the study is to evaluate the efficacy and safety of saredutant (or SR48968C) in patients with depression. The primary objective is to evaluate the efficacy of a 100 mg dose of sareduta...
Detailed Description
The study is a multicenter, multicountry, randomized, parallel-group, double blind, placebo and paroxetine-controlled study consisting of three segments (A, B, and C). Segment A is a 1-week, placebo, ...
Eligibility Criteria
Inclusion
- Male or female patients.
- 18 to 64 years of age.
- Inpatients or outpatients.
- Written informed consent from the patient and/or legally authorized representative.
- Able to comply with the protocol and follow written and verbal instructions.
- Subjects of childbearing potential must have a confirmed negative serum b-hCG test prior to entry into Segment B and must employ an acceptable method of birth control (e.g., oral, depot, or implanted contraceptive method, IUDs, sterilization, barrier methods in conjunction with spermicide).
- Diagnosis of major depressive disorder, as defined by Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revision criteria and confirmed by the semi-structured Mini International Neuropsychiatric Interview (MINI), recurrent episode for at least one month prior to the entry.
- Minimum total score of 22 on the Montgomery-Asberg Depression Rating Scale (MADRS).
Exclusion
- Patients whose current depressive episode is diagnosed with psychotic features, catatonic features, seasonal pattern or post-partum onset.
- The duration of the current depressive episode is greater than 2 years.
- Patients who are currently suicidal or have a history of a suicide attempt within 3 years prior to entry.
- Patients whose current depressive episode is secondary to a general medical disorder.
- Patients with a history or presence of bipolar disorders or psychotic disorders according to the D and L criteria of the MINI.
- Patients with alcohol dependence or abuse or substance dependence or abuse in the past 12 months except nicotine or caffeine dependence.
- Patients with a history of failure to respond to treatment with paroxetine or other antidepressant medications.
- Patients who have used the following prior to entry into Segment B: any antipsychotic within 3 months,-fluoxetine within 35 days, -any monoamine oxidase inhibitor within 21 days, any other antidepressant, anxiolytic, sedative-hypnotic, or mood-stabilizer (lithium, anticonvulsants) within 7 days except permitted concomitant medications.
- Females who are pregnant or breast-feeding.
- 10\. evere or unstable cardiovascular, renal, hepatic, respiratory, hematological, endocrinological, neurological, or other somatic disease that might interfere with the evaluation of study medication.
- History of seizures other than a single childhood febrile seizure.
- ECG abnormalities of potential clinical significance including a QT interval with Bazett's correction of 500 msec or more at entry.
- Use of known inducers or potent inhibitors of CYP3A4 within 7 days of entry.
- Use of drugs with known risk for Torsade de Pointes within 7 days of entry into Segment B.
- Participation in a clinical trial of an experimental therapy within 30 days prior to entry or prior participation in a clinical trial of saredutant.
- Patients with a positive HbsAg or anti-HCV antibody test at screening.
- Patients with any of the following at screening: ALT \>2 times the upper limit of the normal range (XULN), AST \>2XULN, GGT \>3XULN, total or conjugated bilirubin \>ULN
Key Trial Info
Start Date :
December 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2006
Estimated Enrollment :
465 Patients enrolled
Trial Details
Trial ID
NCT00250627
Start Date
December 1 2004
End Date
December 1 2006
Last Update
December 23 2008
Active Locations (8)
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1
Sanofi-Aventis Administrative Office
Laval, Canada
2
Sanofi-Aventis Administrative Office
Santiago, Chile
3
Sanofi-Aventis Administrative Office
Zagreb, Croatia
4
Sanofi-Aventis Administrative Office
Prague, Czechia