Status:
TERMINATED
MPAACS: Magnesium for the Prevention of Atrial Arrhythmias After Cardiac Surgery
Lead Sponsor:
University of British Columbia
Collaborating Sponsors:
Heart and Stroke Foundation of Canada
Conditions:
Coronary Artery Disease
Valvular Heart Disease
Eligibility:
All Genders
20+ years
Phase:
PHASE3
Brief Summary
The objective of our research is to determine whether treatment with magnesium will reduce the incidence of atrial fibrillation in patients undergoing cardiac surgery. Several small studies of magnesi...
Detailed Description
All patients referred for non-emergent cardiac surgery for isolated CABG, isolated valvular heart surgery, or combined valvular and CABG surgery are eligible for the study. Subjects will be randomized...
Eligibility Criteria
Inclusion
- patient undergoing coronary artery bypass surgery with or without valve procedure
- scheduled for on-pump or cardiopulmonary bypass protocol
Exclusion
- existing atrial fibrillation/flutter in the past year or on antiarrhythmic medications
- ventricular fibrillation
- sustained ventricular tachycardia
- 2nd or 3rd degree heart block
- paroxysmal supraventricular tachycardia
- major aortic repair planned during open-heart procedure
- permanent atrial/ventricular pacemaker implanted
- dialysis dependent or creatinine clearance \< 35 umoles/min or oliguric/anuric renal failure
- patient intolerant of beta blockers
- patient has reactive airways disease dependent on regular beta-adrenergic agents
- patient is scheduled to undergo off-pump surgical protocol
Key Trial Info
Start Date :
July 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2009
Estimated Enrollment :
927 Patients enrolled
Trial Details
Trial ID
NCT00250965
Start Date
July 1 2004
End Date
February 1 2009
Last Update
November 4 2010
Active Locations (2)
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1
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1L7
2
St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6