Status:
COMPLETED
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs
Lead Sponsor:
National Taiwan University Hospital
Collaborating Sponsors:
Department of Health, Executive Yuan, R.O.C. (Taiwan)
Conditions:
Adverse Effects
Eligibility:
All Genders
16+ years
Phase:
NA
Brief Summary
Transporters in kidney are critical in detoxification and elimination of xenobiotics from systemic circulation, and thus are major determinants of drug response and sensitivity. Transporters in the re...
Detailed Description
Beta-lactam antibiotics, aminoglycosides, amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs, antineoplastic, or antivirus drugs that are used extensively in clinical settings bear the...
Eligibility Criteria
Inclusion
- Subjects 16 years of age or older, of either sex.
- Subjects have a medication including vancomycin
- Subjects have realistic expectations of the benefit and limitation of the augmentation procedure, as determined by a willingness to sign the informed consent form after it has been carefully explained.
Exclusion
- Subjects have a medical condition that increased the risks of study participation (including pregnancy and poor renal function)
- Subjects are taking medications (nephrotoxicants) that could confound study results.
- Subjects presenting with history of autoimmune disorder, septic shock, or multiple organ failure.
- Subjects with renal failure undergoing dialysis (hemodialysis \[HD\] or continuous ambulatory peritoneal dialysis \[CAPD\]), continuous venovenous hemofiltration (CVVH), or continuous arteriovenous hemodiafiltration (CAVHDF).
Key Trial Info
Start Date :
July 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2006
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT00251017
Start Date
July 1 2005
End Date
June 1 2006
Last Update
December 27 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Surgery, National Taiwan University Hospital
Taipei, Taiwan, 100