Status:
COMPLETED
Catheter-Directed Venous Thrombolysis in Acute Iliofemoral Vein Thrombosis
Lead Sponsor:
Oslo University Hospital
Collaborating Sponsors:
Ostfold Hospital Trust
Conditions:
Deep Vein Thrombosis
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Deep vein thrombosis (DVT) is a severe disease, and conventional treatment with low molecular weight heparin (LMWH) and warfarin is associated with some degree of long-term sequelae, i.e. post-thrombo...
Eligibility Criteria
Inclusion
- Onset of symptoms \<21 days
- Objectively verified DVT of the femoral or common iliac veins or the combined iliofemoral segment
- Informed consent
Exclusion
- Anticoagulant therapy prior to trial entry \>7 days
- Contraindications to thrombolytic therapy
- Indications for thrombolytic therapy, i.e. phlegmasia coerulea dolens or vena cava thrombosis
- Severe anemia, hemoglobin (hgb)\<8 g/dl
- Thrombocytopenia, platelets \<80x10\^9/l
- Severe renal failure, creatinine clearance \<30ml/min
- Severe hypertension, systolic (syst) blood pressure (BP)\>160 mmHg or diastolic (diast) BP \>100 mmHg pregnancy
- Less than 14 days post-surgery or post-trauma
- History of subarachnoidal or intracerebral bleeding
- Disease with life expectancy \<24 months
- Drug abuse or mental disease that may interfere with treatment and follow-up
- Former ipsilateral proximal DVT
- Chemotherapy or advanced malignant disease
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
209 Patients enrolled
Trial Details
Trial ID
NCT00251771
Start Date
January 1 2006
End Date
December 1 2014
Last Update
April 30 2015
Active Locations (1)
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1
Ullevaal University Hospital
Oslo, Oslo County, Norway, 0407