Status:
COMPLETED
BNP (Nesiritide) vs. Placebo to Protect Kidney Function in Patients Undergoing Heart Bypass Surgery.
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
Scios, Inc.
Conditions:
Acute Kidney Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
Use of BNP (nesiritide) vs placebo to help protect kidney function in patients undergoing heart bypass surgery.
Detailed Description
This is a randomized, double-blind, placebo controlled study of low dose nesiritide to prevent renal insufficiency after cardiopulmonary bypass surgery. Patients included are those with greater than m...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients \> 18 years old, undergoing cardiac surgery requiring cardiopulmonary bypass with baseline creatinine clearance \< 50 ml/min and who are not dialysis dependent.
- Exclusion criteria:
- Cardiogenic shock or hypotension with systolic BP \< 90 mmHg.
- Patients with acute or chronic aortic dissection.
- Patients who are enrolled in other studies that have an effect the renal function.
Exclusion
Key Trial Info
Start Date :
March 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2007
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00252200
Start Date
March 1 2003
End Date
October 1 2007
Last Update
September 23 2009
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Mayo Clinic
Rochester, Minnesota, United States, 55905