Status:
COMPLETED
Genetic and Biochemical Markers of Interferon-Induced Depression.
Lead Sponsor:
US Department of Veterans Affairs
Conditions:
Depression
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to identify predictors and associated biochemical markers of interferon-induced depression. It is hypothesized that genetic variation in genes related to the serotonergic ...
Detailed Description
1. Objective of project: Interferon-a (IFN)-induced depression is a common complication of its use in treating patients for hepatitis C (HCV), with reports of up to 44% of patients experiencing these ...
Eligibility Criteria
Inclusion
- Serum positive for hepatitis C
- Age 18 or older
- Not pregnant and using adequate contraception
- Hepatologist-determined patient is a candidate for interferon therapy
- Written/signed informed consent specific for this protocol has been obtained prior to entry
Exclusion
- Diagnosis of active: depression, psychotic symptoms, or bipolar disorder (or history of bipolar disorder) during the previous 3 months
- On antidepressant medications for any reason
- Currently abusing any substances such as alcohol or intravenous drugs, or having abused in the past 6 months.
Key Trial Info
Start Date :
April 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
133 Patients enrolled
Trial Details
Trial ID
NCT00252538
Start Date
April 1 2006
End Date
September 1 2009
Last Update
December 11 2014
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
VA Medical Center, Long Beach
Long Beach, California, United States, 90822
2
VA Medical Center, Minneapolis
Minneapolis, Minnesota, United States, 55417
3
VA Medical Center, Portland
Portland, Oregon, United States, 97201