Status:
COMPLETED
Levetiracetam in Chronic Neuropathic Pain Following Spinal Cord Injury
Lead Sponsor:
Danish Pain Research Center
Collaborating Sponsors:
UCB Nordic A/S
Conditions:
Injuries, Spinal Cord
Pain
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Purpose: To evaluate the efficacy and safety of levetiracetam on chronic neuropathic pain after spinal cord injury, and to examine its effect on spasms and evoked pain.
Detailed Description
Study design: Randomized double-blind cross-over study of levetiracetam (Keppra) against corresponding placebo with a 1 week baseline period followed by 2 x 5 weeks treatment periods separated by a 1 ...
Eligibility Criteria
Inclusion
- 1\. age 18 or more
- 2\. neuropathic pain (that have lasted at least 3 month) after a spinal cord injury with a pain intensity of at least 4 on a 0-10 point numeric rating scale
Exclusion
- 1\. pregnancy or lactation
- 2\. allergy to levetiracetam
- 3\. alcohol or substance abuse, mental disease, epilepsy, depression and psychiatric disorders, severe liver disease, decreased kidney function, and known concomitant cerebral damage
Key Trial Info
Start Date :
November 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00252954
Start Date
November 1 2005
End Date
December 1 2008
Last Update
August 20 2009
Active Locations (3)
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1
Danish Pain Research Center, Aarhus University Hospital
Aarhus, Denmark, 8000
2
Clinic for Spinal Cord Injuries, Rigshospitalet
Hornbæk, Denmark, 3100
3
The Spinal Cord Unit, Dept of Rheumatology
Viborg, Denmark, 8800