Status:
COMPLETED
Effect of Simvastatin on CF Airway Inflammation
Lead Sponsor:
Akron Children's Hospital
Collaborating Sponsors:
Cystic Fibrosis Foundation
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
10+ years
Phase:
PHASE1
Brief Summary
Individuals with cystic fibrosis (CF) have persistent infection in the airways, which the body attempts to fight by recruiting immune cells (neutrophils) to the lung. The immune system and neutrophils...
Detailed Description
Cystic Fibrosis (CF) lung disease is characterized by chronic bacterial infection and excessive inflammation. The airways of patients with CF contain large amounts of neutrophils, neutrophil products,...
Eligibility Criteria
Inclusion
- Cystic Fibrosis
- \> 9 yrs of age
- Clinically stable
- FEV1 \> 50% predicted
Exclusion
- Hepatic disease
- B. cepacia
- corticosteroids
- symptomatic allergic rhinitis
Key Trial Info
Start Date :
July 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2009
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00255242
Start Date
July 1 2004
End Date
May 1 2009
Last Update
August 3 2009
Active Locations (1)
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1
Akron Children's Hospital
Akron, Ohio, United States, 44308