Status:
COMPLETED
Influence of Hydroxyehtyl Starch (HES) on Hemorehology, Coagulation and Elimination Kinetics
Lead Sponsor:
Nizam's Institute of Medical Sciences University, India
Conditions:
Stroke Patients Presenting Within 24 Hrs of Onset of Symptoms
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The use of HES has been found clinically to improve patients with stroke if administered within a window period by means of hemodilution to improve rehology. We propose to see the effects of long term...
Detailed Description
Patients with stroke benefit with hemodilution when administered HES in a window period and continued for a period of 10 days. Hemodilution improves the hemorheology and thus possibly preserves the ce...
Eligibility Criteria
Inclusion
- Age 18 - 70 yrs Clinical diagnosis of ischemic stroke No marked spontaneous improvement of symptoms before randomization Written informed consent from nearest relative.
- \-
Exclusion
- Pregnancy Allergy to HES Severe impairment of consciousness Previous stroke with persistent ipsilateral deficits. Seizure at stroke onset. Intracranial neoplasm or AV malformation. Cardiac insufficiency or pulmonary edema Myocardial infarction during the previous 3 months or unstable angina. Severe dehydration Coagulation disorders. Uncontrolled Hypertension. Laboratory findings reflecting severe anemia, renal insufficiency, thrombocytopenia or hepatic insufficiency.
- Participation in another clinical trial within the previous 2 months or concurrent treatment with any other experimental drug.
- SECONDARY EXCLUSION CRITERIA.
- Cerebral CT at enrolment showing intracranial hemorrhage of any degree-
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
End Date :
March 1 2006
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00255957
Start Date
October 1 2005
End Date
March 1 2006
Last Update
April 19 2006
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