Status:
COMPLETED
Essential Fatty Acids for Major Depression
Lead Sponsor:
University of Iowa
Conditions:
Major Depression
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
This is a research study to determine whether omega-3 fatty acid supplementation, when taken with the antidepressant medication escitalopram (Lexapro), helps to improve depressive symptoms in individu...
Detailed Description
Primary aims Aim 1: To determine whether measures of essential fatty acid (EFA) membrane composition predict symptom improvement during selective serotonin reuptake inhibitor (SSRI) treatment of majo...
Eligibility Criteria
Inclusion
- DSM-IV criteria for nonpsychotic MDD
- Not currently on antidepressants OR not responding to a stable dose of antidepressants
Exclusion
- DSM-IV for substance abuse in past month or dependence past year.
- Allergy to fish
- Bleeding disorder or taking warfarin
- Omega-3 supplements for more than three consecutive days in the preceding month
- Pregnant
- Taking medications (i.e. glucocorticoids) known to produce affective symptoms
- History of non-response to escitalopram
- DSM-IV for an eating disorder in the preceding year.
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2007
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00256412
Start Date
October 1 2005
End Date
October 1 2007
Last Update
June 5 2008
Active Locations (1)
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1
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States, 52242