Status:
COMPLETED
Endophenotype for Alcohol Misuse in Healthy Minority Populations
Lead Sponsor:
University of Pennsylvania
Conditions:
Healthy
Eligibility:
All Genders
21+ years
Phase:
PHASE4
Brief Summary
The purpose of the study is to understand the relationship between what an individual inherited from their family (genetics), how they respond and feel after drinking alcohol, and how they respond to ...
Detailed Description
We propose to test the degree to which specific genetic markers alter the relationship between subjective and objective measures of response to alcohol ingestion among non-alcohol dependent adults of ...
Eligibility Criteria
Inclusion
- Male or female and 21 years of age or older
- Drinks less than an average of 21 drinks/week with no more than 2 binge episodes per week
- Of African descent by self report
Exclusion
- Meets DSM-IV criteria for lifetime dependence on any substance other than nicotine
- Subjects who test positive on the urine drug screen for opioids, cocaine, marijuana, or amphetamine at the screening visit
- Subjects who meet current or lifetime DSM-IV criteria for bipolar affective disorder, schizophrenia, or any psychotic disorder
- The presence of unstable or serious medical illness; including history of stroke, seizure disorder, severe liver disease (AST or ALT \> 5X normal at the time of randomization), or unstable cardiac disease
- Needs treatment with any psychotropic medication (antidepressant, antipsychotic, benzodiazepine, or mood stabilizing medication)
- Pre-menopausal female subjects who are pregnant, nursing, or not using a reliable method of contraception
- Insulin-dependent diabetes
- Any medical or psychological condition that could jeopardize the subject's safe participation in the trial as determined by the PI.
Key Trial Info
Start Date :
November 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2008
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT00256451
Start Date
November 1 2005
End Date
May 1 2008
Last Update
August 21 2019
Active Locations (1)
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1
University of Pennsylvania Treatment Research Center
Philadelphia, Pennsylvania, United States, 19104