Status:
COMPLETED
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease
Lead Sponsor:
Memory Pharmaceuticals
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
50-90 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine in a 12-week treatment study if MEM 1003 is a safe and effective treatment for patients with mild to moderate Alzheimer's disease.
Detailed Description
Alzheimer's disease is the leading cause of dementia and one of the most common diseases of the aging population. It is a chronic brain disease that involves gradual memory loss, decline in the abilit...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- standardized MMSE Score of 10 to 24 points
- diagnosis of probable Alzheimer's disease
- magnetic resonance imaging or computed tomography examination compatible with AD
- modified Hachinski Ischemia Score of less than or equal to 4
- currently receiving no AD therapy or currently receiving donepezil, rivastigmine, or galantamine
- Exclusion criteria:
- head injury associated with cognitive impairment
- history of vascular dementia stroke, transient cerebral ischemic episodes, major depression, major psychotic disorder, or symptomatic postural hypotension
- treatment for Alzheimer's disease other than donepezil, rivastigmine, or galantamine; tacrine is not permitted in the last 30 days or memantine in the last 90 days
- treatment with calcium channel blockers or any investigational medications within the prior 30 days
Exclusion
Key Trial Info
Start Date :
November 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2007
Estimated Enrollment :
183 Patients enrolled
Trial Details
Trial ID
NCT00257673
Start Date
November 1 2005
End Date
October 1 2007
Last Update
May 6 2008
Active Locations (57)
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1
Northport, Alabama, United States, 35476
2
Mesa, Arizona, United States, 85201
3
Phoenix, Arizona, United States, 85013
4
Sun City, Arizona, United States, 85351