Status:
COMPLETED
Immune Response to Mycobacterium Tuberculosis Infection
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Latent Tuberculosis
Eligibility:
All Genders
18+ years
Brief Summary
This study will examine how the immune system responds to infection with Mycobacterium tuberculosis bacteria (bacteria that cause tuberculosis) in order to better understand how the germ produces infe...
Detailed Description
Tuberculosis (TB) is a major global health concern. One third of the world's population is infected with Mycobacterium tuberculosis. Two to 3 million people die every year of the disease with 8-10 mil...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age18 yrs. or older.
- Adequate venous access.
- Willingness to allow blood samples to be used for future studies of immune function and disease pathogenesis.
- Ability to give informed consent and willingness to comply with study requirements and procedures.
- Willingness to have PPD placed.
- Willingness to undergo HIV testing.
- EXCLUSION CRITERIA:
- Hgb less than or equal to 7.9 g/dl
- A known medical disorder or other circumstance which in the opinion of the PI might make the participation of the individual unsafe or difficult.
- Active TB or a history of treated tuberculosis infection.
- Presently suffering from an acute infection.
- History of a severe reaction to PPD application or known allergy to a component of the PPD.
- Severe burns or Eczema.
- PPD less than or equal to 8 weeks previously.
Exclusion
Key Trial Info
Start Date :
November 18 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 24 2016
Estimated Enrollment :
157 Patients enrolled
Trial Details
Trial ID
NCT00257907
Start Date
November 18 2005
End Date
February 24 2016
Last Update
April 5 2018
Active Locations (2)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
2
Mali-NIAID HIV Research Initiative FMPOS
Bamako, Mali