Status:
COMPLETED
Predictor of Advanced Sub-Clinical Atherosclerosis (PASA) Study
Lead Sponsor:
University of Wisconsin, Madison
Conditions:
Atherosclerosis
Eligibility:
All Genders
30-80 years
Phase:
NA
Brief Summary
The study will evaluate the clinical utilization of skin Cholesterol (SC) for cardiovascular risk assessment in asymptomatic individuals at low, intermediate and high risk based on Framingham global r...
Detailed Description
* The primary objective of the study will be to determine the relationship between skin cholesterol levels and carotid artery intima-media thickness (CIMT), a surrogate marker for atherosclerotic burd...
Eligibility Criteria
Inclusion
- Informed written consent from the subject prior to testing.
- Males or females 30-80 years of age
Exclusion
- 1\. Known coronary heart disease, (history of myocardial infarction, coronary bypass surgery, coronary angioplasty, or angina pectoris with a positive stress test or angiographic documentation)
- Known peripheral vascular disease (claudication with ankle-brachial index \< 0.9, angioplasty, or peripheral artery bypass procedure)
- Known cerebrovascular disease (stroke or TIA with documented carotid or aortic atherosclerosis)
- History of carotid artery endarterectomy or carotid artery surgery
- Diabetes mellitus (fasting glucose \> 126 mg/dL, on on insulin-reducing medications)
- 10-year Framingham risk of cardiac death or MI using ATP III calculator \>20%
- Subjects taking cholesterol-lowering medications
- Known hepatitis
- Known pregnancy
- Skin disease on either hand (e.g. eczema psoriasis, rash or broken skin)
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
End Date :
November 1 2007
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT00258999
Start Date
October 1 2005
End Date
November 1 2007
Last Update
October 5 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Wisconsin
Madison, Wisconsin, United States, 53792