Status:
COMPLETED
The Role of Peptide YY (PYY)Infusions in Inhibiting Food Intake.
Lead Sponsor:
University of Copenhagen
Collaborating Sponsors:
EC-FP6 (contract number: LHM-CT-2003-503041)
Aditech Pharma AB
Conditions:
Obesity
Eligibility:
MALE
20-50 years
Phase:
NA
Brief Summary
The aim of the study is to compare fasting and postprandial PYY levels between overweight/obese and lean subjects during and after an infusion of saline, PYY1-36 or PYY3-36 and to evaluate the efects ...
Detailed Description
The study is a randomised dobbelblinded placebo controlled study with 24 male subjects ( 12 lean and 12 overweight/obese subjects). VAS scores are used to assess appetite and two ad libitum meals are ...
Eligibility Criteria
Inclusion
- Normal weight (BMI: 18-23 kg/m2) or 12 overweight/obese (BMI: 27-40 kg/m2)
- Body weight fluctuations \< 5 kg over the past 2 months.
- Blood pressure normal to mildly hypertensive (\<159/99 mm Hg)
- Non-elite athletes and not planning to change physical activity during the study.
Exclusion
- Any physiological or psychological illnesses that could influence the study results
- Regular use of medicine
- Smoking defined as \<1 cigarette per day.
- Substance abuse or dependence.
- Blood donation within the past 3 months before entering the study
- Drinking \>21 alcoholic units/week.
- Food allergies.
- Special diets (e.g. vegetarian) or dislikes to any of the foods served during the study.
Key Trial Info
Start Date :
June 1 2004
Trial Type :
INTERVENTIONAL
End Date :
November 1 2005
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00259246
Start Date
June 1 2004
End Date
November 1 2005
Last Update
January 21 2009
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