Status:
UNKNOWN
Access, Detection and Psychological Treatments
Lead Sponsor:
Ontario Mental Health Foundation
Conditions:
Psychoses
Eligibility:
All Genders
12-30 years
Phase:
NA
Brief Summary
Schizophrenia is one of society's most costly medical conditions and the most severe among psychiatric disorders. One of the most important and exciting new concepts in psychiatry is that detection an...
Detailed Description
Research Stream 1: Treatment and Cost Effectiveness The primary aim of Stream 1 is to evaluate the effectiveness of a model-driven psychological intervention, CBT in preventing or delaying the onset ...
Eligibility Criteria
Inclusion
- Ages 12-30 years·
- Meeting criteria for an "at risk mental state" based on one or more of the 3 Criteria of Prodromal Symptoms (COPS criteria) with severity as determined by ratings on the Scale of Prodromal Symptoms (SOPS) or the criteria for attenuated symptoms of the early prodromal state defined by the presence of at least two of 9 symptoms on the Bonn Scale for the Assessment of Basic Symptoms that have been demonstrated to have the best positive predictive value of developing schizophrenia (Klosterkötter et al., 2001). These criteria for the early prodromal state course are currently used in the multi-site European Prediction of Psychosis Study (EPOS) (Birchwood et al., 2002).
Exclusion
- Meets criteria for current or lifetime axis I psychotic disorder.·
- Meets DSM-IV criteria for an Axis 1 disorder where in the judgment of the evaluating clinician the diagnostic prodromal symptoms are clearly caused by the Axis 1 disorder. Note that, except for bipolar and psychotic disorders and a current major depression other DSM-IV disorders will not be exclusionary (e.g. substance abuse or dependence disorder, major depression, anxiety disorders, Axis II Disorders) as long as the disorder does not account for the diagnosis of prodromal symptoms.·
- Use of substances where in the judgment of the evaluating clinician, the diagnostic prodromal symptoms are substance-induced.
- Prior history of treatment with an antipsychotic for the current presenting symptoms or for any previous episode of psychotic symptoms.
- Impaired intellectual functioning (IQ\< than 70).
- Past or current history of a clinically significant central nervous system disorder which may confound or contribute to prodromal symptoms.
Key Trial Info
Start Date :
August 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2008
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT00260273
Start Date
August 1 2004
End Date
August 1 2008
Last Update
November 8 2007
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Centre for Addiction and Mental Health
Toronto, Ontario, Canada, M5T 1R8