Status:
COMPLETED
Effects of Gynecological Age on LH Sensitivity to Energy Availability
Lead Sponsor:
Ohio University
Collaborating Sponsors:
Ohio State University
Conditions:
Anovulation
Amenorrhea
Eligibility:
FEMALE
18-34 years
Phase:
NA
Brief Summary
The purpose of this experiment is to investigate whether the dependence of luteinizing hormone pulsatility on energy availability declines during adolescence.
Detailed Description
The incidence of menstrual disorders declines during adolescence. This has long been attributed to the gradual "maturation" of the hypothalamic-pituitary-ovarian axis, but the mechanism of this "matur...
Eligibility Criteria
Inclusion
- 5-8 or 14-18 years of gynecological age
- menstrual cycles of 26 to 32 days for the previous 3 months
- luteal phase length \>11 days
- 18-32% body fat
Exclusion
- smoking
- oral contraceptives
- hematocrit \<35%
- diet with \<35 or \>55 kcal/kgFFM/day of energy
- habitually performing more than 60 minutes/week of aerobic exercise
- histories or evidence of heart, liver, or kidney disease, diabetes, menstrual or thyroid disorders, pregnancy, lactation, and congenital or acquired orthopedic abnormalities
Key Trial Info
Start Date :
August 1 2001
Trial Type :
INTERVENTIONAL
End Date :
May 1 2004
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00260286
Start Date
August 1 2001
End Date
May 1 2004
Last Update
December 5 2005
Active Locations (1)
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1
Ohio University
Athens, Ohio, United States, 45701