Status:
UNKNOWN
Protective Ventilatory Strategy in Potential Organ Donors
Lead Sponsor:
University of Turin, Italy
Collaborating Sponsors:
Ministry of Health, Italy
Conditions:
Mechanical Ventilation
Eligibility:
All Genders
18-65 years
Phase:
PHASE3
Brief Summary
The aim of the study is to verify if a "PROTECTIVE" ventilatory strategy (low tidal volume and high PEEP, application of CPAP during the apnea test and recruitment maneuvers), improves lung function a...
Detailed Description
Lung transplantation reduces mortality in patients with severe pulmonary diseases. While 50-70% of kidney, liver and heart are eligible for transplantation, only 20% of the lungs fit the criteria for ...
Eligibility Criteria
Inclusion
- Age: 18-65 years
- Chest X-ray: no infiltrates
- Duration of mechanical ventilation from the admission to ICU to the clinical diagnosis of brain death \< 5 days
- No history of Smoking (1 pack/day for 20 years; 1/2 pack/day for 40 years; 2 packs/day for 10 years)
- No history of Asthma
- No history of COPD
- No history of Trauma
- No history of Thoracic surgery
Exclusion
- Evidence of aspiration (chest X-ray or bronchoscopy) or sepsis
- Purulent secretions (tracheal suction or bronchoscopy)
- Sputum Gram stain with bacteria, fungus, significant number of WBC
Key Trial Info
Start Date :
September 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2010
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00260676
Start Date
September 1 2004
End Date
January 1 2010
Last Update
June 17 2009
Active Locations (1)
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1
University of Turin, Department of Anesthesia and Intensive Care Medicine
Turin, Italy, 10126