Status:
WITHDRAWN
Rituximab Treatment to Block HLA Antibodies in Renal Transplant Recipients
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
Genentech, Inc.
Conditions:
Chronic Rejection
Kidney Insufficiency
Eligibility:
All Genders
18-64 years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study is to determine if administration of rituximab blocks the development of donor specific antibodies (DSA) in transplant recipients who have developed renal dysfunction and DSA...
Detailed Description
A long established risk factor for late renal allograft loss is the development of DSA. Recent studies from our group and others have shown that these antibodies are probably responsible for chronic r...
Eligibility Criteria
Inclusion
- Recipient of a primary cadaver or living donor renal allograft
- 18-64 years of age
- At least 6 months and no more than 10 years post renal transplant
- Serum clearly positive for defined DSA
- Renal biopsy positive for C4d staining within 28 days before study Day 1 treatment
- Blood positive for Cd 19/20 cells at greater than/equal to 50 % of lower limit of normal
- Baseline serum creatinine 1.7-3.0 mg/dl
- On stable doses of tacrolimus and MMF for at least 1 month prior to study entry
- Able and willing to sign IRB approved consent form and comply with the requirements of the screen, treatment and follow-up phase of the protocol
- Negative serum pregnancy test (women of child bearing potential)
- Men and women of reproductive potential agree to use an acceptable method of birth control during treatment, for twelve months after treatment completion, or until B cell counts return to normal, whichever is longer
Exclusion
- Hemoglobin: \< 8.5 gm/dL
- Platelets: \< 100.00/mm
- White blood cell count: \< 3000/mm3
- AST or ALT . 2.5 x Upper Limit of Normal unless related to primary disease
- Positive Hepatitis B or C serology
- History of positive HIV
- Treatment with any investigational agen within 4 weeks of screening or 5 half-lives of the investigational drug (whichever is longer)
- Receipt of a live vaccine within 4 weeks prior to study entry
- Previous treatment with rituximab (rituxan)
- History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies
- History of recurrent infections
- Known active bacterial, viral, fungal, mycobacterial or other infection or any major episode of infection requiring hospitalization or treatment with intravenous antibiotics within 4 weeks of screening or oral antibiotics within 2 weeks prior to screening
- Ongoing use of high dose steroids (\>10mg/day) or unstable steroid dose in the past 4 weeks.
- Lack of peripheral venous access
- History of drug, alcohol or chemical abuse within 6 months prior to screen
- Pregnancy or lactation
- Concomitant malignancies or previous malignancies
- History of psychiatric disorder that would interfere with normal participation in this protocol
- Significant cardiac or pulmonary disease
- Any other disease, metabolic dysfunction, physical examination finding or clinical lab finding giving reasonable suspicion of disease or condition that contraindicates use of an investigational drug or that may affect the interpretation of the results or render subject a high rist from treatment complications
- Inability to comply with study and follow-up procedures
Key Trial Info
Start Date :
December 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2007
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00261547
Start Date
December 1 2005
End Date
November 1 2007
Last Update
October 23 2023
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