Status:
UNKNOWN
Hereditary Nonpolyposis Colorectal Cancer in Taiwan-Related Genetic Study and Clinical Applications
Lead Sponsor:
National Health Research Institutes, Taiwan
Collaborating Sponsors:
Chang Gung Memorial Hospital
Conditions:
Hereditary Nonpolyposis Colorectal Cancer
Eligibility:
All Genders
20+ years
Brief Summary
The purpose of this study is to establish the HNPCC related information in Taiwan, and to characterize relevant susceptibility genes related to colorectal cancer to provide better disease control for ...
Detailed Description
HNPCC is an autosomal dominant disease that is clinically characterized by the development of colorectal cancer (CRC) at an early age (mean age 44 years old). Four genes have been known to be related ...
Eligibility Criteria
Inclusion
- Select all affected individuals. If the affected is unavailable, select the spouse and adult children (20+) of these unavailable affected individuals.
- Select unaffected individuals in the following priority order:
- study both parents of the affected individuals;
- if parents are not available, study up to two siblings of each missing parent (if both parents are deceased, study four siblings - two from each parent);
- study up to five unaffected siblings (age 20 or older) of the affected individual; if more than five siblings are available for study, select the siblings from oldest to youngest;
- study up to three children (age 20 or older) of the affected individual; again, select the three oldest children if more than three are available;
- if the two affected individuals in the multiplex family are not siblings, (first cousins, for example, then study common grandparents - if common grandparents are not available, study siblings of these grandparents) when children of the affected individual's are studied, the child's unaffected parent will also be selected for study.
Exclusion
- N/A
Key Trial Info
Start Date :
May 1 2002
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2016
Estimated Enrollment :
1014 Patients enrolled
Trial Details
Trial ID
NCT00262171
Start Date
May 1 2002
End Date
August 1 2016
Last Update
April 7 2016
Active Locations (1)
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1
Division of Biostatistics and Bioinformatics, National Health Research Institites
Miaoli County, Taiwan, 350