Status:
TERMINATED
Recruitment Maneuvers in ARDS: Effects on Respiratory Function and Inflammatory Markers.
Lead Sponsor:
University Hospital, Tours
Conditions:
Acute Lung Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Acute Respiratory Distress Syndrom is associated to lung and systemic inflammation, which could be worsened by mechanical ventilation.This included a proteasis - antiproteasis imbalance which could pa...
Eligibility Criteria
Inclusion
- age over 18
- hospitalization in the ICU
- under mechanical ventilation
- Acute Lung Injury (ALI)criteria
- first week of ALI
- hemodynamic stability (mAP \> 75 mmHg since one hour)
- informed consent signed (patient or relatives)
Exclusion
- pregnancy
- obesity (BMI \> 40 kg/M2)
- high probability of D-28 death
- severe burn injury
- severe hepatic cirrhosis (Child-Pugh C)
- aplasia
- HIV or CHV infection
- use of more than 0.5 mg/kg of steroïds
- immunosuppressor agents
- hemopathy
- contra indications for BAL
- contra indications for recruitment maneuvers
- baro-traumatism
- left cardiac failure
- chronic respiratory failure
- inclusion in another study during the past month
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2006
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00263146
Start Date
September 1 2005
End Date
January 1 2006
Last Update
January 16 2017
Active Locations (1)
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1
University Hospital of Tours
Tours, France, 37044