Status:
COMPLETED
PET Imaging of Brain 5-HT(1A) Receptors Using [(11)C](-)-RWAY
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Healthy Volunteers
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
This study will use positron emission tomography (PET) and magnetic resonance imaging (MRI) to measure a serotonin receptor subtype in the brain called 5-HT(1A). This receptor is a target for drug the...
Detailed Description
The 5-hydroxytryptamine (serotonin, 5-HT) 5-HT(1A) receptors subtype is a target for drug therapy in the treatment of anxiety and depression. Radioligands currently in use with PET for studying human ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- All subjects must be healthy and aged 18-65 years.
- EXCLUSION CRITERIA:
- Current psychiatric illness, substance abuse or severe systemic disease based on history and physical exam.
- Any existing physical exam and ECG within one year will be reviewed and if none already exists in the chart, these will be obtained and reviewed.
- Laboratory tests with clinically significant abnormalities.
- Prior participation in other research protocols or clinical care in the last year such that radiation exposure would exceed the annual limits.
- Pregnancy and breast feeding.
- Claustrophobia.
- Presence of ferromagnetic metal in the body or heart pacemaker.
- Positive HIV test.
- A history of brain disease.
Exclusion
Key Trial Info
Start Date :
December 5 2005
Trial Type :
INTERVENTIONAL
End Date :
August 15 2007
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00263523
Start Date
December 5 2005
End Date
August 15 2007
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892