Status:
COMPLETED
An fMRI Study of the Effect of Intravenous Oxytocin vs. Placebo on Response Inhibition and Face Processing in Autism
Lead Sponsor:
Anagnostou, Evdokia, M.D.
Conditions:
Autism
Eligibility:
All Genders
18-50 years
Phase:
PHASE1
Brief Summary
To study the effect of oxytocin on face processing and response inhibition in autistic adults by fMRI.
Detailed Description
Autism is a developmental disorder affecting approximately 60/10,000 individuals. It is characterized by social and language deficits and repetitive behaviors/restricted interests. Functional imaging ...
Eligibility Criteria
Inclusion
- Meet DSM-IV, ADI, or ADOS criteria for autism spectrum disorder.
- Age 18-50.
- Be seen as outpatients
- IQ\>80
- 5\. Demonstrate capacity to provide authorized informed consent or provide consent for participation by an approved surrogate on the autistic individual's behalf
Exclusion
- Subjects who are pregnant or nursing mothers. Sexually active women of childbearing potential who are not using adequate birth control measures.
- Subjects with epilepsy.
- Subjects with a history of schizophrenia, schizoaffective disorder or other Axis 1 mental disorders, such as bipolar disorder.
- Subjects reporting history of encephalitis, phenylketonuria, tuberous sclerosis, fragile X syndrome, anoxia during birth, neurofibromatosis, hypomelanosis, hypothyroidism, Duchenne muscular dystrophy, and maternal rubella
- Subjects who have received depot neuroleptic medication, or other psychoactive drugs within the past 5 weeks.
- Subjects with renal or liver disease or abnormalities in blood chemistry.
- Any metallic prosthesis such as plates, pins and screws, shrapnel, metallic foreign body, vascular or neurosurgical clips that may be incompatible with the MRI and any electrical devices such as a pacemaker or a defibrillator
- Claustrophobia
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2012
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00263796
Start Date
March 1 2006
End Date
September 1 2012
Last Update
April 30 2014
Active Locations (1)
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1
Mount Sinai School of Medicine
New York, New York, United States, 10029-6574