Status:
COMPLETED
Study of ADH-1 Given Intravenously to Patients With Solid Tumors
Lead Sponsor:
Adherex Technologies, Inc.
Conditions:
Neoplasms
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
N-cadherin, a protein involved in blood vessel cell binding, is increased as cancer progresses, and is on the surface of many tumor cells. ADH-1 blocks N-cadherin. This study will test the safety and ...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Signed written informed consent
- Male and female patients \> or = 18 years of age with a solid tumor(s) refractory to standard curative therapy or for which no curative therapy exists. Study currently enrolling only patients with non-small cell lung cancer or advanced ovarian cancer to the safety expansion phase.
- Clinically or radiologically documented measurable disease.
- Immunohistochemical evidence of N-cadherin expression (at least 1+ positive) in archived or fresh tumor tissue
- Adequate performance status and organ function, as evidenced by hematological and biochemical blood testing and electrocardiogram (ECG)
- Exclusion criteria:
- Receipt of ADH-1 prior to this clinical study
- Chemotherapy, radiotherapy, or any other investigational drug within 30 days before study entry
- History of primary brain tumors or brain metastases (known or suspected) unless any lesions have completely resolved following appropriate treatment and there has been no recurrence for at least 6 months. History of spinal cord compression. History of tumors that have shown clinically significant evidence of active bleeding (e.g., gross hemoptysis, hematemesis, hematuria, melena, or bleeding superficial tumor) within 12 weeks before study entry.
- Stroke, major surgery, or other major tissue injury within 30 days before study entry
- History of congestive heart failure, myocardial infarction, angina, life threatening arrhythmias, significant electrocardiogram (ECG) abnormalities, or known hypercoagulable states
Exclusion
Key Trial Info
Start Date :
June 1 2005
Trial Type :
INTERVENTIONAL
End Date :
January 1 2008
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00265057
Start Date
June 1 2005
End Date
January 1 2008
Last Update
December 28 2010
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
Istituto Nazionale per lo Studio e la Cura dei Tumori
Milan, Italy, 20133
2
Instituto Europeo di Oncologia
Milan, Italy, 20141
3
Istituto Oncologico della Svizzera Italiana
Bellinzona, Switzerland, 6500