Status:
TERMINATED
Pain Treatment After Total Knee Replacement - Continuous Epidural Versus Intravenous Patient Controlled Analgesia With Morphine
Lead Sponsor:
Rambam Health Care Campus
Conditions:
Pain, Postoperative
Osteoarthritis
Eligibility:
All Genders
55-85 years
Phase:
PHASE4
Brief Summary
The study purpose is to compare the effectiveness of different methods for post-operative pain treatment after total knee replacement.
Detailed Description
Total knee replacement (TKR) is known to be one of the most painful surgical procedures. Many treatments have been used post TKR: IV opioids, epidural infusions, peripheral nerve blocks. No one method...
Eligibility Criteria
Inclusion
- Informed consent
- Age: 55 to 85 years
- Osteoarthritis
- Primary unilateral total knee replacement
- American Society of Anesthesiologists (ASA) I-III
- Successful spinal epidural anesthesia for surgery
Exclusion
- Any cause for knee replacement other than osteoarthritis
- Total knee revision (re-do)
- Any contraindication for regional anesthesia
- Abnormal coagulation studies
- Thrombocytopenia less than 100,000/cc
- Chronic renal failure (creatinine \[cr\] \< 1.8)
- Neurological disease involving lower extremities
- Major surgery during the last 2 weeks pre-operatively
- Current or past drug or alcohol abuse
- Allergy to study medications
- Post-operative bleeding over 2000 cc/24 hours
- Postdural puncture headache after anesthesia performance
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
End Date :
March 1 2007
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00270322
Start Date
January 1 2006
End Date
March 1 2007
Last Update
April 11 2007
Active Locations (1)
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1
Rambam Health Care Campus
Haifa, Israel, 31096