Status:
COMPLETED
Correlation of Endothelial Function and Early Coronary Artery Disease in Humans
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Endothelial Dysfunction
Eligibility:
All Genders
18-85 years
Phase:
PHASE3
Brief Summary
Qualifying patients who are scheduled for angiogram with endothelial function testing are approached to participate in this protocol (consent form reviewed with patient). Those who are willing to part...
Detailed Description
Aim I: To determine the activity of the endogenous endothelin system in the coronary circulation in humans with coronary endothelial dysfunction and atherosclerosis risk factors. Aim II: To assess the...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age \> 18 years and \< 85 years
- Male or female
- Exclusion criteria:
- Left dominant circulation
- Heart failure with EF \<40%
- Unstable angina
- MI or angioplasty of the LAD or circumflex with 6 months prior to entry into the study
- Use of radiographic contrast agent within 12 hours of entry into the study
- Use of investigational agents within one month of entry into the study
- Patients who require treatment with positive inotropic agents other than digoxin during the study
- Patients with cerebrovascular accident within 6 months prior to entry into the study
- Significant endocrine, hepatic, renal disorders; local or systemic infectious disease within 4 weeks prior to entry into study
- Pregnancy or lactation
- Mental instability
- Federal Medical Center patients
Exclusion
Key Trial Info
Start Date :
July 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00271492
Start Date
July 1 2001
End Date
January 1 2008
Last Update
April 30 2010
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905