Status:
COMPLETED
Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
National Center for Research Resources (NCRR)
Conditions:
Sleep Deprivation
Eligibility:
All Genders
18-40 years
Brief Summary
Work requirements for medical trainees result in substantial sleep loss. Sleep loss has been associated with increased levels of certain inflammatory hormones that could have negative impact on blood ...
Detailed Description
Context: Sleep loss is associated with increased blood levels of interleukin-6 (IL-6) and C-reactive protein (CRP). Medical residents are often deprived of normal sleep during extended work shifts, bu...
Eligibility Criteria
Inclusion
- Medical resident in MICU rotation
- Non-smoker
- Body mass index \<28 kg/m2
Exclusion
- Systolic blood pressure \>140 mmHg; Diastolic blood pressure \>90 mmHg
- Known history of diabetes mellitus, hypertension, hyperlipidemia
- Known history of acute or chronic inflammatory or infectious disease
- Known history of sleep disturbance unrelated to work
- Pregnancy
Key Trial Info
Start Date :
December 1 2004
Trial Type :
OBSERVATIONAL
End Date :
June 1 2005
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00272233
Start Date
December 1 2004
End Date
June 1 2005
Last Update
March 20 2007
Active Locations (1)
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1
Yale University School of Medicine
New Haven, Connecticut, United States, 06510