Status:
COMPLETED
Prevention of Nosocomial Infection by Decontamination of the Naso- and Oropharynx With Chlorhexidine (NONI Trial)
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborating Sponsors:
Onze Lieve Vrouwe Gasthuis
Conditions:
Nosocomial Infection
Respiratory Tract Infection
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Does chlorhexidine gluonate, a simple broad-spectrum antimicrobial agent with virtually no adverse-effects lower the incidence of NI after cardiac surgery, especially with respect to LTI and SSI?
Detailed Description
Nosocomial infections (NIs) after open heart surgery are recognized as an important cause of morbidity and mortality with a prolonged hospital stay, increased need for of antibiotics, decreased qualit...
Eligibility Criteria
Inclusion
- all adult patients (above 18) who were scheduled to undergo sternotomy for cardiothoracic surgery
Exclusion
- emergency procedures, a preoperative infection and/or the use of antibiotics, hypersensitivity to chlorhexidine gluconate (CHX), absence of written informed consent or presence of an alternative prophylactic regimen like selective decontamination of the digestive tract
Key Trial Info
Start Date :
August 1 2003
Trial Type :
INTERVENTIONAL
End Date :
September 1 2005
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT00272675
Start Date
August 1 2003
End Date
September 1 2005
Last Update
January 9 2006
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Onze lieve vrouwe gasthuis
Amsterdam, Netherlands, 1090 HM