Status:
COMPLETED
Electrical Polarization of the Brain in Corticobasal Syndrome
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Corticobasal Syndrome
Eligibility:
All Genders
40-90 years
Phase:
PHASE2
Brief Summary
This study will test whether DC electrical polarization of the brain can temporarily improve hand function in patients with corticobasal syndrome (CBS). In this degenerative disorder of the brain, ner...
Detailed Description
Objective: In a recent sham-controlled pilot study, we showed that surface anodal direct current (DC) polarization can improve verbal fluency in frontotemporal dementia patients. Corticobasilar syndro...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Clinically diagnosed CBS, consisting of progressive asymmetric rigidity and apraxia and additional findings suggesting cortical (e.g., one or more of the following: alien limb phenomenon, apraxia of speech, cortical sensory loss, constructional dyspraxia, hemisensory neglect, myoclonus, mirror movements) and basal ganglionic (e.g., one or more of the following: bradykinesia, dystonia, tremor, postural instability) dysfunction.
- Patients fitting these criteria will be identified among those referred to protocol 02-N-0001. All must have been evaluated under this protocol.
- Enough residual hand function on one side to perform the tests.
- Age greater than or equal to 40: This limit is justified because the diagnosis of CBS would be very uncertain in anyone under this age.
- EXCLUSION CRITERIA:
- Presence of metal in the cranial cavity or calvarium.
- Uncontrolled medical problems, such as uncontrolled diabetes mellitus, hypertension, airway disease, heart failure, coronary artery disease, or any other condition that poses a risk for participation.
- Broken skin in the area of the electrodes.
Exclusion
Key Trial Info
Start Date :
December 30 2005
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00273897
Start Date
December 30 2005
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892