Status:
COMPLETED
Bendamustine and Rituximab in Treating Patients With Previously Untreated or Relapsed Chronic Lymphocytic Leukemia
Lead Sponsor:
German CLL Study Group
Collaborating Sponsors:
University of Cologne
Conditions:
Chronic Lymphocytic Leukemia
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
CLL2M is a phase 2, multicenter, open label study to investigate the possible therapeutic benefits of using bendamustine in combination with rituximab for the treatment of patients with previously unt...
Detailed Description
Conventional chemotherapy and also high dose chemotherapy with autologous stem cell transplantation are not curative treatment options in B-CLL; nearly all patients will eventually relapse. Also monoc...
Eligibility Criteria
Inclusion
- 18 years of age or older
- Diagnosis of B-CLL in need of treatment
- Previously untreated Binet stage C or Binet B with need of treatment according to NCI-criteria
- Relapsed or refractory disease after at least one but not more than 3 prior regimens. Patients who previously received bendamustine must have had at least a partial response with duration of response of at least six months.
- World Health Organization performance status of 0-2
- Life expectancy \>12 weeks
- Anti-cancer therapy, major surgery, or irradiation was completed \>3 weeks before registration in this study. Patient must have recovered from the acute side effects incurred as a result of previous therapy.
- Serum creatinine ≤1.5 the institutional upper limit of normal (ULN) or Creatinine clearance \>30 ml/min/1.73 m²
- Adequate liver function as indicated by a total bilirubin, AST, and ALT ≤2 the institutional ULN value, unless directly attributable to the patient's tumor.
- Female patients with childbearing potential must have a negative serum pregnancy test within two weeks of first dose of study drug(s). Male and female patients must agree to use an effective contraceptive method while on study treatment and for a minimum of six months following study therapy.
- Signed, written informed consent.
Exclusion
- Previously treated with \>3 prior regimens for B-CLL.
- Known central nervous system (CNS) involvement with B-CLL.
- Patients who have progressed with more aggressive B-cell cancers such as Richter's syndrome.
- History of anaphylaxis following exposure to monoclonal antibodies.
- Known to be human immunodeficiency virus (HIV), hepatitis B, or C positive.
- Active infection or history of severe infection (grade 4) within 3 months prior to study registration.
- Medical condition requiring prolonged use of oral corticosteroids (\> 1 month).
- Use of investigational agents within 30 days prior to study randomization.
- Active secondary malignancy.
- ANC \<1.5x109/L or platelet count \<75x109/L, unless due to bone marrow involvement of CLL.
- Other severe, concurrent diseases, including tuberculosis, mental disorders, serious cardiac functional capacity (Class III or IV as defined by the New York Heart Association Classification), severe diabetes, severe hypertension, pulmonary disease (chronic obstructive pulmonary disease \[COPD\] with hypoxemia), or major organ malfunction (liver, kidney) that could interfere with the patient's ability to participate in the study.
- Pregnant or nursing women.
- Any circumstance at the time of study entry that would preclude completion of the study or the required follow-up.
- Participation in another clinical trial
Key Trial Info
Start Date :
November 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
195 Patients enrolled
Trial Details
Trial ID
NCT00274989
Start Date
November 1 2005
End Date
March 1 2011
Last Update
May 23 2019
Active Locations (58)
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1
Internistische Praxis - Arnstadt
Arnstadt, Germany, 99310
2
Klinikum Augsburg
Augsburg, Germany, D-86156
3
HELIOS Klinikum Bad Saarow
Bad Saarow, Germany, 15526
4
Internistische Gemeinschaftspraxis - Berlin
Berlin, Germany, 13347