Status:
COMPLETED
Spironolactone to Decrease Potassium Wasting in Hypercalciurics on Thiazides Diuretics
Lead Sponsor:
Indiana University School of Medicine
Conditions:
Idiopathic Hypercalciuria
Hypokalemia Caused by Thiazide Diuretics
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Kidney stone formation due to an excess of calcium in the urine is a common problem. It is treated with thiazide diuretics. These drugs often cause excessively low blood potassium levels that in turn ...
Detailed Description
See rationale above Ten patients who have had multiple kidney stones primarily due to hypercalciuria and who are currently on stable dose of thiazide or thiazide plus amiloride will be enrolled in th...
Eligibility Criteria
Inclusion
- Age 18-65
- History of idiopathic hypercalciuria (\>200mg per 24 hours or a Ca/cr ratio of \>140) felt to be the primary etiology of patient's kidney stones
- History of at least three kidney stone events
- On same dose of thiazide diuretic for at least three months
- On stable dose of K 60mEq or more a day to maintain serum K \>3.5 or unable to tolerate an increase in K supplement with dose at least 40mEq a day
Exclusion
- Use of ACE inhibitor, ACE receptor blocker or other medication known to effect serum potassium levels
- GFR \<80 by MDRD equation
- Serious cardiac disease, diabetes, CKD , current or planned pregnancy or breastfeeding
- History of hypertension
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2006
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00276289
Start Date
January 1 2006
End Date
June 1 2006
Last Update
December 3 2009
Active Locations (1)
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1
Indiana University Department of Medicine, Division of Nephrology
Indianapolis, Indiana, United States, 46202