Status:
TERMINATED
Gonyautoxin in the Treatment of Chronic Tension-Type Headache
Lead Sponsor:
University of Chile
Conditions:
Tension-Type Headache
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to evaluate the clinical efficacy of Gonyautoxin 2/3 epimers in the treatment of patients diagnosed with chronic tensional-type headache in accordance with International H...
Detailed Description
Gonyautoxin are phycotoxins, whose molecular mechanism of action is a reversible block of the voltage-gated sodium channels at neuronal level. They are axonal conduction blockers impeding nerve impuls...
Eligibility Criteria
Inclusion
- Chronic tensional-type headache patients according to the International Headache Society criteria: patients with headache of a pressing or tightening quality with episodic frequency above 15 days a month
- Refractory to conventional treatments such as, orally administered analgesics, systemic muscular relaxant, corticoids and antidepressant like Amytriptiline
- Treated and controlled in the University Hospital Neurology Clinic over 2 years with duration of symptoms over 3 years
Exclusion
- Pregnancy
- Use of headache prophylactic treatment a month prior to infiltration
- Myasthenic syndromes
- Muscular dystrophies
- Inflammatory myopathies
- Acute and chronic polineuropathies
- Use of psychotropic substances 24-hour before infiltration
- Anticoagulant treatment
- terminal illnesses (AIDS, cancer)
- drugs or alcohol abuse
Key Trial Info
Start Date :
September 1 2004
Trial Type :
INTERVENTIONAL
End Date :
August 1 2005
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT00276952
Start Date
September 1 2004
End Date
August 1 2005
Last Update
January 13 2006
Active Locations (1)
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1
Departament of Neurology and Neurosurgery, Hospital Clínico Universidad de Chile.
Santiago, Santiago Metropolitan, Chile, 0