Status:
WITHDRAWN
Aripiprazole Augmentation Therapy in Treatment-resistant Depression
Lead Sponsor:
University Hospital Freiburg
Conditions:
Therapy-resistant Depression
Eligibility:
All Genders
18-70 years
Phase:
PHASE3
Brief Summary
20 therapy-refractory patients with major depression will be treated for 3 weeks with Aripiprazole 10 mg/d. Effectivity will be assessed using a pre-post comparison of different psychopathological rat...
Detailed Description
This will be an open pilot study using pre-post comparison. 20 treatment-refractory patients with major depression diagnosed by DSM-IV will be included. Psychotic features of depression will be exclud...
Eligibility Criteria
Inclusion
- major depression without psychotic features (DSM-IV definition)
- therapy resistance (two courses of antidepressants from different classes for more than 3 weeks in adequate dose)
- HAM-D score greater/equal than 17
- age 18-70
Exclusion
- bipolar disorder
- active alcohol or illicit drug use
- female without effective contraception
- severe medical conditions
- psychotic features
Key Trial Info
Start Date :
June 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2009
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00276978
Start Date
June 1 2005
End Date
November 1 2009
Last Update
August 10 2022
Active Locations (1)
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1
Dept. of Psychiatry, University of Freiburg
Freiburg im Breisgau, Germany, D-79104