Status:
COMPLETED
Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Typhoid Fever
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
Brief Summary
This study will evaluate a new (conjugate) vaccine for typhoid fever, which remains a serious disease especially difficult to treat in developing countries. Salmonella typhi, the bacteria causing typh...
Detailed Description
Typhoid fever remains a common, serious and increasingly difficult to treat disease in developing countries. Control measures, such as safe drinking water, and food, and effective sewage, are not like...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- To be eligible, volunteers must be 18 to 45 years old, who
- are not participating in or plan to participate in another research protocol during the next three months;
- have not been vaccinated against typhoid fever or had typhoid fever within the last 5 years;
- are not regularly taking a prescription drug for chronic medical condition;
- have no history of allergy to fruit or fruit pectin;
- are not pregnant or intend to become pregnant during the study period of 6 months;
- Whose HIV, HBsAg and HCV tests must be found negative and laboratory tests of liver function, blood chemistry, complete blood count and urine must show no clinically significant abnormality or pregnancy.
Exclusion
Key Trial Info
Start Date :
January 9 2006
Trial Type :
INTERVENTIONAL
End Date :
September 17 2008
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00277147
Start Date
January 9 2006
End Date
September 17 2008
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892