Status:
TERMINATED
Study of XL999 in Patients With Metastatic Colorectal Cancer
Lead Sponsor:
Symphony Evolution, Inc.
Conditions:
Colorectal Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This clinical study is being conducted at multiple sites to determine the activity, safety, and tolerability of XL999 when given weekly to patients with metastatic colorectal cancer (CRC). XL999 is a ...
Eligibility Criteria
Inclusion
- Males and females with histologically confirmed metastatic colorectal cancer
- Measurable disease according to Response Criteria for Solid Tumors (RECIST)
- At least 1 prior therapeutic regimen (chemotherapy or biologic)
- ECOG performance status of 0 or 1
- Life expectancy ≥3 months
- Adequate organ and marrow function
- No other malignancies within 5 years
- Signed informed consent
Exclusion
- Radiation to ≥25% of bone marrow within 30 days of XL999 treatment
- Treatment with systemic anticancer therapy within 30 days of XL999 treatment
- Subject has not recovered to ≤ grade 1 or to within 10% of baseline from adverse events due to other medications administered \>30 days prior to study enrollment
- History of or known brain metastases, current spinal cord compression, or carcinomatous meningitis
- Uncontrolled and/or intercurrent illness
- Pregnant or breastfeeding females
- Known HIV
Key Trial Info
Start Date :
December 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2007
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT00277303
Start Date
December 1 2005
End Date
February 1 2007
Last Update
February 22 2010
Active Locations (8)
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1
California Cancer Care, Inc.
Greenbrae, California, United States, 94904
2
Integrated Community Oncology Network; Division of Clinical Research
Jacksonville, Florida, United States, 32256
3
Hematology Oncology Associated of the Treasure Coast
Port Saint Lucie, Florida, United States, 34952
4
University of Chicago
Chicago, Illinois, United States, 60637