Status:
COMPLETED
Potential Association of a Common L-FABP Polymorphism With Lipid-induced Hepatic Insulin Resistance
Lead Sponsor:
German Institute of Human Nutrition
Conditions:
Wildtype
Polymorphism Liver FABP
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The investigators hypothesise that a common A277G polymorphism of the liver fatty acid binding protein (L-FABP) gene, which leads to an amino acid exchange, may be associated with alterations of lipid...
Detailed Description
Liver fatty acid binding protein (L-FABP) is an abundant cytosolic lipid-binding protein that regulates lipid transport and metabolism. Only one common non-synonymous polymorphism (A227G) leading to a...
Eligibility Criteria
Inclusion
- healthy subjects with normal glucose tolerance (NGT)
Exclusion
- any severe cardiac, liver, or kidney diseases
- pregnant or lactating women, menstrual irregularities
- cortisone, antidiabetic drugs
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
End Date :
April 1 2006
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00277342
Start Date
January 1 2006
End Date
April 1 2006
Last Update
May 4 2012
Active Locations (1)
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1
German Institute of Human Nutrition DIfE, Dpt. of Clinical Nutrition, Potsdam-Rehbrücke
Nuthetal, Germany, 14558