Status:
COMPLETED
Dietary Supplementation With Soy Isoflavones in Asthma
Lead Sponsor:
Northwestern University
Conditions:
Asthma
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
An epidemiologic study of patients with asthma has shown that increased intake of soy isoflavones correlates with less severe asthma. In experimental animals, treatment with the soy isoflavone geniste...
Detailed Description
This is a prospective pilot study to be conducted in 20 subjects with asthma. The participant will undergo the following procedures: 1. Completion of a questionnaire that asks for information about a...
Eligibility Criteria
Inclusion
- Ages 18-50, males and females
- Physician diagnosis of asthma; requires daily asthma medication
- Moderate persistent disease (NAEPP guidelines)
- FEV1 65 to 90% of predicted
- At least 12% increase in FEV1 15-30 minutes after inhaling 2-4 puffs of albuterol or positive methacholine challenge (20% fall in FEV1 at less than 8 mg/ml) - either of these can available from the previous 2 years
- Generally good health
Exclusion
- Oral corticosteroid use within the past 3 months
- Use of high dose inhaled corticosteroids (greater than 500 mcg of fluticasone per day or greater)
- Current or former smoker (quit less than 6 months prior to study enrollment or greater than 10 pack years)
- Recent asthma exacerbation (within 6 weeks)
- Current consumption of soy isoflavone supplements
- Known adverse reaction to genistein, other phytoestrogens, or soy products
- Pregnant
- Unintentional weight loss of more than 10 pounds within the year
- Major or unstable medical condition
- Use of an investigational drug in the previous 30 days
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2007
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT00277446
Start Date
January 1 2006
End Date
April 1 2007
Last Update
February 25 2011
Active Locations (1)
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1
Northwestern University
Chicago, Illinois, United States, 60611