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Status:

COMPLETED

Sorafenib in Treating Patients With Recurrent Non-Hodgkin's Lymphoma

Lead Sponsor:

National Cancer Institute (NCI)

Conditions:

Anaplastic Large Cell Lymphoma

Recurrent Adult Diffuse Large Cell Lymphoma

Eligibility:

All Genders

18+ years

Phase:

PHASE2

Brief Summary

Sorafenib may stop the growth of cancer cells by blocking blood flow to the cancer and by blocking some of the enzymes needed for cell growth. This phase II trial is studying how well sorafenib works ...

Detailed Description

PRIMARY OBJECTIVES: I. Determine the overall response rate, including complete and partial responses, in patients with chemosensitive, relapsed, aggressive, non-Hodgkin's lymphoma treated with sorafe...

Eligibility Criteria

Inclusion

  • Inclusion Criteria:
  • Histologically or cytologically confirmed aggressive\* non-Hodgkin's lymphoma by excisional-node biopsy or core needle biopsy and bone marrow biopsy, including 1 of the following types:
  • Mantle cell lymphoma
  • Primary mediastinal large B-cell lymphoma
  • Diffuse large B-cell lymphoma
  • Anaplastic large cell lymphoma (T-cell or null-cell type)
  • Recurrent disease
  • Patients must have received ≥ 1 induction regimen containing anthracyclines (e.g., CHOP \[with or without rituximab\] or R-EPOCH)
  • Chemosensitive disease at the time of relapse
  • Patients who responded with a complete or partial remission that lasted at least 8 weeks after their last chemotherapy regimen are considered chemosensitive
  • Measurable disease, defined as a lymph node or a nodal mass of \> 1 cm in its longest transverse diameter on CT scan
  • Ineligible for, refused, or relapsed after stem cell transplant (for patients with non-mantle cell lymphoma)
  • No known brain metastases, including meningeal involvement
  • ECOG performance status (PS) 0-2
  • Karnofsky PS 60-100%
  • Life expectancy \> 3 months
  • WBC ≥ 3,000/mm\^3
  • Absolute neutrophil count ≥ 1,500/mm\^3
  • Platelet count ≥ 100,000/mm\^3
  • Bilirubin normal
  • AST and ALT ≤ 2.5 times upper limit of normal
  • Creatinine normal OR creatinine clearance ≥ 60 mL/min
  • Fertile patients must use effective contraception
  • Not pregnant or nursing
  • Negative pregnancy test
  • No uncontrolled illness
  • No history of allergic reactions attributed to compounds of similar chemical or biologic composition to sorafenib
  • No known positive HIV serology
  • No inflammatory bowel disease
  • No swallowing dysfunction that would prevent ingestion of pills
  • No hemorrhagic diathesis
  • No ongoing or active infection
  • No symptomatic congestive heart failure
  • No unstable angina pectoris
  • No cardiac arrhythmia
  • No uncontrolled hypertension
  • No psychiatric or social situation that would limit compliance with study requirements
  • No poorly controlled medical condition that would seriously complicate compliance with this study
  • Patients with inflammatory or exfoliative skin disease are excluded (regardless of the extent of the involvement) unless the skin condition is lymphoma related
  • See Disease Characteristics
  • Previous treatment-related toxic effects should be resolved to grade 1 or better
  • No chemotherapy or radiation therapy within the past 4 weeks
  • 6 weeks for nitrosoureas or mitomycin C
  • No prior antibody therapy for at least 3 months
  • Prior radiation for localized disease or total body irradiation as part of a conditioning regimen prior to stem cell transplant allowed
  • Prior radio-immunotherapy allowed
  • No concurrent therapeutic anticoagulation
  • Prophylactic anticoagulation (i.e., low-dose warfarin) of venous or arterial access devices are acceptable provided that the requirements for PT, INR, and PTT are met
  • No concurrent use of another investigational agent
  • No concurrent use of the following drugs: phenytoin, carbamazepine, phenobarbital, rifampin, or Hypericum perforatum (St. John's wort)
  • No other concurrent anticancer therapy

Exclusion

    Key Trial Info

    Start Date :

    October 1 2005

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ACTUAL

    End Date :

    Estimated Enrollment :

    33 Patients enrolled

    Trial Details

    Trial ID

    NCT00278382

    Start Date

    October 1 2005

    Last Update

    February 7 2013

    Active Locations (1)

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    Page 1 of 1 (1 locations)

    1

    University of Maryland Greenebaum Cancer Center

    Baltimore, Maryland, United States, 21201-1595