Status:
COMPLETED
Levetiracetam Treatment of Panic Disorder and Lactate-Induced Panic Attacks
Lead Sponsor:
Lindner Center of HOPE
Collaborating Sponsors:
UCB Pharma
University of Cincinnati
Conditions:
Panic Disorder
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The main purpose of this research study is to determine whether the drug Levetiracetam (Keppra™) is effective in the prevention of panic attacks. The drug Levetiracetam (Keppra™) has been approved for...
Detailed Description
a) Methods and Procedures: Study Treatment: Study drug and dosing: Levetiracetam open-label, with the following titration schedule to begin after the initial lactate infusion: Study day Levetiracet...
Eligibility Criteria
Inclusion
- Outpatient subjects age 18 years or older.
- Subjects must meet DSM-IV-TR criteria for panic disorder with or without agoraphobia.
- Subjects must experience a minimum of one panic attack per week over the month preceding the study.
- Subjects must be fluent in English.
- Subjects must be able to provide and understand written informed consent.
Exclusion
- Subjects unable to provide and understand written informed consent.
- Subjects previously treated with levetiracetam.
- Subjects who meet DVM-IV-TR criteria for current diagnosis of mood, psychotic or substance use disorder.
- Subjects who have acute or unstable medical illness.
- Subjects with a history of seizures or structural brain damage from trauma.
- Subjects currently receiving successful treatment for panic disorder (i.e., subjects will not have medications discontinued to participate in the study if they are effective in the treatment of their panic attacks).
- Subjects susceptible to lactate infusions.
- Female subjects who are pregnant or lactating.
- Female subjects who, if fertile, are not using medically acceptable and reliable method of contraception.
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2009
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00279617
Start Date
January 1 2006
End Date
March 1 2009
Last Update
December 13 2011
Active Locations (1)
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1
University of Cincinnati Medical Center
Cincinnati, Ohio, United States, 45267-0559