Status:
COMPLETED
Comparison of Alveolar Macrophages in Individuals With COPD Versus Smokers With Normal Pulmonary Function
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Pulmonary Disease, Chronic Obstructive
Lung Diseases, Obstructive
Eligibility:
All Genders
40+ years
Brief Summary
The purpose of this study is to determine whether the alveolar macrophages (AMø) of patients with chronic obstructive pulmonary disease (COPD ) show abnormal responsiveness to bacterial and viral prod...
Detailed Description
BACKGROUND: COPD is one of the most pressing healthcare problems facing our nation. Acute exacerbations of COPD (AE-COPD) are responsible for the bulk of healthcare costs, and much of the morbidity a...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Diagnosis of COPD and/or chronic bronchitis (study group, following American Thoracic Society guidelines)
- Willingness to participate in follow-up studies defined in the protocol
- Ability to give informed consent
- Already undergoing clinically indicated bronchoscopy
- Exclusion criteria:
- Unstable cardiovascular disease
- Other systemic disease in which survival of more than 2 years is unlikely
- Mental incompetence or active psychiatric illness
- Currently taking more than 20 mg/day of Prednisone
- Participation in another experimental protocol within 6 weeks of study entry
- Asthma
- Cystic fibrosis
- Clinically significant bronchiectasis
- Lung cancer
- Other inflammatory or fibrotic lung disease
Exclusion
Key Trial Info
Start Date :
September 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2014
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00281190
Start Date
September 1 2005
End Date
October 1 2014
Last Update
December 16 2014
Active Locations (1)
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1
University of Michigan at Ann Arbor
Ann Arbor, Michigan, United States, 48105